Testosterone is a male hormone that helps develop and maintain muscle mass, bone density, libido, and sperm production. Testosterone levels naturally decrease after puberty and continue to decline throughout adulthood. However, testosterone supplementation may help men who have low testosterone levels due to aging, injury, illness, or medical conditions.
Testosterone is produced by the body’s adrenal glands and gonads (testes). In males, testosterone is primarily produced by Leydig cells in the testes. In females, testosterone is produced by the ovaries.
Testosterone is converted into estrogen in women. Estrogen is a female sex hormone that regulates menstruation, pregnancy, lactation, sexual desire, and many other bodily processes.
The effects of testosterone vary depending on the amount present in the body. Low levels of testosterone are associated with decreased muscle mass, reduced libido, fatigue, depression, and erectile dysfunction. High levels of testosterone are associated increased aggression, risk-taking behavior, and improved mood.
There are two types of testosterone: endogenous (produced by the body) and exogenous (supplemented). Endogenous testosterone is produced by the body at different rates throughout the day. Exogenous testosterone is taken in pill form and is absorbed directly into the bloodstream.
Testosterone is classified as a prohormone because it is converted into several other hormones before reaching target organs. These hormones include dihydrotestosterone (DHT), estradiol, estrone, androstenedione, and progesterone. Dihydrotestosterone is the primary active metabolite of testosterone.
Testosterone is considered anabolic if it increases lean muscle mass and decreases fat mass. Anabolic steroids increase protein synthesis and inhibit protein degradation. Proteins are the building blocks of muscles. Protein synthesis occurs when the body uses amino acids to build new proteins. Protein degradation occurs when the body breaks down existing proteins.
Testosterone is categorized as anabolic if it increases muscle size and strength. Testosterone does not affect muscle mass alone; it affects the rate at which muscles break down and rebuild themselves. Muscle breakdown is called catabolism. Muscle rebuilding is called anabolism.
Testosterone is anabolic if it increases bone mineral density. Bone mineral density refers to the amount of bone mass per unit volume of bone. Bones become denser over time as they lose weight and become less porous. As bones get older, they become less dense.
Testosterone is antiandrogenic if it reduces the activity of the androgen receptor. Androgens are male hormones that stimulate masculine characteristics. Testosterone works by binding to the androgen receptor. When testosterone binds to the androgen receptor, it activates genes that promote the growth of hair, skin, prostate, and penis.
Testosterone is aromatase inhibitor if it inhibits the conversion of testosterone into estrogen. Aromatase inhibitors prevent the conversion of testosterone into estradiol. Estradiol is a female hormone that stimulates breast enlargement, lubricates the vagina, and promotes menstrual cycles.
Testosterone is a precursor to estrogen. If testosterone is converted into estrogen, then estrogen will be produced instead of testosterone. Therefore, testosterone is an aromatase inhibitor if its conversion into estrogen is inhibited.
Testosterone is antigonadotropic if it suppresses the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). LH and FSH are hormones that regulate the reproductive system.
Testosterone is androgenic if it stimulates the development of male genitalia. Testosterone is also known as androgen.
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